12 For these reasons, there is a broad consensus amongst the clinical and basic AKI research communities that development of the first effective disease modifying treatments for AKI will address an important, unmet medical need. 11 In a 2018 report by MarketWatch, the number of AKI patients in 2016 was estimated to be over 1.5M with the market size being $4.3B in the seven major markets including the US, EU5 (Germany, Spain, Italy, France, and UK), and Japan. 5– 8 In terms of the scale of the problems, AKI has been reported to complicate up to 20% of hospitalizations 9, 10 with a prevalence rate estimated to be 1.8 in 1000 in the general population in a 2007 study. Currently, no therapeutic interventions have been shown to definitively prevent AKI, improve recovery, or improve long-term outcomes after AKI, including CKD, ESRD or death. 2– 4 Despite the clinical significance of this problem, supportive care, avoiding additional kidney injury, and when possible, removing the initial injurious event, are the primary treatment options. 2– 4 AKI from any cause is a strong, independent predictor of mortality, and often results in incomplete recovery, giving rise to CKD, and in some patients, end stage renal disease (ESRD). 2– 4 AKI also commonly occurs in association with comorbidities including pre-existing chronic kidney disease (CKD), old age, diabetes and heart failure, all of which increase the risk of AKI and may influence the underlying pathobiology and response to treatment. 1– 3 Despite this simple and homogeneous definition, AKI is in fact a highly heterogeneous clinical syndrome that is precipitated by different injurious events, often in combination, including dehydration, heart failure, blood loss, major trauma including surgery and crush injury, sepsis and chemical toxicities. This review will examine and make the case that CO be developed into a therapeutic agent against AKI.Īcute kidney injury (AKI) is a common, global health concern that manifests as a rapid decline in kidney function that occurs over a 7-day period or less. This is particularly important in treating cisplatin-induced AKI, a common clinical problem that develops in patients receiving cisplatin therapies for a number of different solid organ malignancies. CO has also been shown to sensitize cancer, but not normal cells, to chemotherapy. Along this line, carbon monoxide (CO) has emerged as a promising therapeutic agent because of its demonstrated cytoprotective, and immunomodulatory effects. However, over the same time period, new understanding of the underlying pathobiology and molecular mechanisms of kidney injury have undoubtedly helped the search for new therapeutics. Over the years, there has been much effort in search of therapeutics with minimal success. There is also a large untapped market opportunity in treating AKI. Treating acute kidney injury (AKI) represents an important unmet medical need both in terms of the seriousness of this medical problem and the number of patients.
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In 2003, she played the lead role in the movie ‘Game Over.’ She took a break from acting due to personal issues. In the years since, she has appeared in several television films, including ‘It Came from the Sky’ and ‘Ultimate Deception’ in 1999, and ‘Hidden War’ and ‘Titans’ (lead role) in 2000. ‘Undercover Angel’ and ‘Coming Soon’ were two other romantic films she appeared in the same year. The following year, she starred in the romantic film ‘Heaven or Vegas,’ which was released in 1999. She had a significant role in the sports comedy film ‘BASEketball’ in 1998. In 1998, she played a supporting role in the police drama series ‘Nash Bridges.’ In 1994, she appeared in the thriller film ‘The Force.’ She appeared in a few more television films, including ‘A Face to Die For,’ ‘Talk to Me,’ and ‘Crowned and Dangerous,’ all in 1996. She re-enacted this role in the 1995 television film ‘Baywatch the Movie: Forbidden Paradise.’ She also appeared as a guest star in a spin-off series called ‘Baywatch Night.’ More Yasmine received praise for her portrayal of Caroline Holden. Her breakthrough came with the release of her drama series “Baywatch” in 1993. She was a regular on the television show “One Life to Live” from 1991 to 1993. The show became very popular, and she won several Emmy Awards for it. She played a supporting role in the soap opera ‘Ryan’s Hope’ between 19. She has done several noble works for the betterment of people’s lives as a philanthropist. Her role as Caroline in the top-rated action drama series ‘Baywatch’ catapulted her to fame. With her role in the TV series ‘Ryan’s Hope,’ she made her television debut. Yasmine Bleeth Yasmine Bleeth’s Profession & Career Her height is 5 feet 5 inches, and she weighs 60 kg. Yasmine Bleeth, who was born on June 14, 1968, is 54 years old as of today, September 19, 2022. Yasmine Bleeth’s Age, Height, Weight, and Body Dimensions She played an orphan in the film as a child artist. When she was 12, she was cast in the film ‘Hey Babe!’ (1980). While she was appearing in a Max Factor advertisement, a famous fashion photographer named ‘Francesco Scavullo’ offered her and her mother a role in ‘Scavullo Women.’ She began doing advertisements for a few local brands when she was a child. List is made up of films like Baywatch: Hawaiian Wedding and The Force.Her parents were in the entertainment industry, which aided her in establishing a foundation in acting. The greatest Yasmine Bleeth performances didn't necessarily come from the best movies, but in most cases they go hand in hand. If you think the best Yasmine Bleeth role isn't at the top, then upvote it so it has the chance to become number one. If you and a friend are arguing about this then use this list of the most entertaining Yasmine Bleeth films to end the squabble once and for all. Yasmine Bleeth has been in a lot of films, so people often debate each other over what the greatest Yasmine Bleeth movie of all time is. The order of these top Yasmine Bleeth movies is decided by how many votes they receive, so only highly rated Yasmine Bleeth movies will be at the top of the list. Yasmine Bleeth's highest grossing movies have received a lot of accolades over the years, earning millions upon millions around the world. List of the best Yasmine Bleeth movies, ranked best to worst with movie trailers when available. “When Christmas decorations finally go up…” 19) Funny Christmas cat memes! “Dashing through the no.” 17) Also, define inappropriate dirty Christmas memes. “Christmas cookies? No, I haven’t seen any Christmas cookies.” 16) Funny Christmas Grumpy Cat memes. “Come sit on Santa’s lap and we can talk about the first thing that pops up!” 14) Dirty Christmas memes when you’re broke. “Coffee!!! I need more coffee!!!!” 13) Let’s include inappropriate dirty “Christmas memes” for good measure. “Hallelujah! Holy s#!t! Where’s the Tylenol!” 12) Christmas now.” 11) Funny “Christmas Vacation” memes! “Celebrated Christmas before the birth of Christ.” 10) Funny then and now Christmas memes. “My cat forgets what a Christmas tree is every year and it’s wonderful.” 9) Are Christmas memes technically birthday memes? “When you can’t afford Christmas decorations.” 8) Christmas is coming.” 7) Funny Christmas decorating memes. “Made this so when my boss shouts at me through his office door, it’s more festive.” 6) Brace yourselves. “The tree has been up for five minutes.” 5) “I don’t always give presents on Christmas but when I do, it’s because I took an arrow to the knee.” 3) Funny Christmas memes featuring our favorite elf! “Christmas shopping? Ain’t nobody got money for that.” 2) Enjoy! 1) Let the funny Christmas memes begin! Make Xmas even merrier by sharing some of these funny memes with your friends and family during the Xmas holidays. We did the heavy lifting for you and compiled some of the best funny memes you’ll ever find. Make the holidays stress-free by taking the time to laugh and smile and think of us as your holiday headquarters for some of the funniest Christmas memes. The Christmas season is a time to get together with friends and family but it can get hectic at times. In terms of holidays, none are as special and bring a family together more than Christmas. More details on software and accessibility are available at. For visitors with visual disabilities, access to this website, including our FICO Data Privacy Policy, is available through assistive technologies, such as BrowseAloud, JAWS, VoiceOver, Narrator, ChromeVox, and Window-Eyes. Further information is available in our FICO Data Privacy Policy. 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If you use direct deposit, they make it available a day or two early, sometimes even sooner than that. Some credit unions have early direct deposit. For that reason, let me guide you through this easy method to fold your homemade crunshwrap to perfection! But we can't always leave the house to indulge in every fast-food craving that comes crashing down on us in the middle of the night. Taco Bell's amazingly delicious hybrid of a taco/burrito Mexican fusion is almost everyone's guilty pleasure. How can we make this recipe feasible for keto diet?Ī piece of cabbage can imitate tortillas used in traditional crunchwrap with some crunch cheese crisps and all the other keto friendly filling ingredients used in this recipe. Just keep in mind that it may not wrap as well, or cover all of the crunchwrap ingredients. Storing the leaves may take away some of its delicious crunch, but that's okay the taste will still be as amazing as it should be! Finally, I think butter lettuce would be a good option too. If you are planning on making this green crunchwrap often, then you can store your boiled cabbage large leaves in the freezer for later use. I would recommend carefully removing the cabbage spine for ease in folding. Use two sets of tongs, one to remove cabbage leaf from the base and the second set of tongs to hold the cabbage steady or use a slotted spoon to remove each leaf to a colander set over a bowl and let drain. To Start, preheat your oven to 400☏ and line a baking sheet with parchment paper then in a large pot of salted boiling water cook the cored cabbage for about 2 minutes until crisp tender. Experiment a little by substituting your tortilla wrap with some cabbage or butter lettuce! ! Now this is something you don't see every day.A green crunchwrap! A soft spot for taco bell's, You heard that right. Finally, I brought you a fun little assignment substitute the keto tortilla wrap with a different vessel! Try this recipe with low carb wraps such as green cabbage or lettuce, isn't it a great idea! Wipe that confused expression out, and let me guide you through it! Second, if you are not a huge meat fan, or looking for some variety, then swap the meat with chicken. It is one of the family keto-friendly meals, and customizable to your liking! Here are a few suggestions to twist this amazing recipe into your own! First, feel free to add or swap any of the ingredients mentioned with others that you think will complement the final flavor. The best real thing about this Easy Keto Crunchwrap recipe is how adaptable it is! You can swap, omit, or even add some ingredients. Consider this Easy Keto Crunchwrap Supreme recipe a healthier copycat of the original thing! Same great taste, way less carbs! The wraps are loaded with seasoned beef, cheese, sour cream, and vegetables! Toasted to golden perfection, this wrap is a highly demanded item and a crowd favorite. To all of you who haven't tried Taco Bell's Crunchwrap Supreme.You are missing out! Crunchwrap Supremes are one of Taco Bell's most famous menu items. Mission Carb Balance Tortillas are high in fiber and protein, and would make a wonderful low-carb solution for a crunchwrap craving. For my Easy Keto Crunchwrap Supreme recipe, using Mission Carb Balance Tortillas, allowed me to create a wholesome low-carb dish without losing the amazing flavors. And if I learned anything throughout my life, it is that cutting carbs out doesn’t necessarily mean cutting on deliciousness. I guess we all learned the hard way that a diet shouldn't be an act of self-punishment. 1 overall in the 2018 draft, may finally play up to his full potential with a couple of star receivers and a strong supporting cast. That obvious self-observation aside, Mayfield, who went No. With those two wideouts on the perimeter, Mayfield could see a bump in his completion rate.Īs Mayfield said in a press conference after signing a one-year, $4 million deal with the Buccaneers, he'll never be Brady. Evans finished with 1,035 yards on the season, the eighth consecutive year he's topped 1,000 yards - an NFL record to begin a career (Randy Moss is second on the all-time list with six). If the offensive line holds up, he can pick and choose his spots to attack defenses downfield.Įven though Mayfield isn't known to have a strong arm, he flashed decent accuracy at the tail-end of the previous campaign with the Rams' makeshift receiving corps, completing 63.6 percent of his passes in five games.Īt 6'5", 231 pounds, Evans is a big target, and Godwin catches like a Venus flytrap on the boundary with a 71.5 percent catch rate. 10 hours ago &0183 &32 Year 2 is the breakout age for QBs selected in the first round, with Carson Wentz (2017), Patrick Mahomes (2018), Lamar Jackson (2019), Kyler Murray (2020), Joe Burrow (2021) and Trevor Lawrence. Mike Evans averages for the NBA season and Playoffs, including points, rebounds, assists, steals, blocks and other categories, year by year and career numbers. With Canales coming from Seattle to Tampa Bay, he could carry over some of the Seahawks' principles in the ground game to elevate the Buccaneers' rushing attack.īetween the play-caller and the plethora of targets in the passing game, Mayfield is set up for success in Tampa Bay. He now trails only 49ers legend Jerry Rice, who eclipsed 1,000 yards in 11 straight seasons from 1986-1996.While Smith had a standout 2022 campaign, the Seahawks' ground attack ranked seventh in yards per carry (4.8) and registered 133-plus yards in each of the last three regular-season games (2-1 in that stretch). Buccaneers quarterback Tom Brady had a passer rating of 127 when he targeted Evans last season. The only other receivers who scored more touchdowns than Evans (13) were Davante Adams (18), Tyreek Hill (15), and Adam Thielen (14). Now with nine straight, Evans is tied with another Hall of Famer, longtime Raiders star Tim Brown, for the second-longest overall streak of 1,000-yard receiving seasons in NFL history. However, Evans averaged 15.5 PPR fantasy points per game, finishing as a WR2 or better in 56 of his games. Hall of Famer Randy Moss held the record previously, with six straight. The four-time Pro Bowler first set the record for most consecutive 1,000-yard seasons to start a career when he logged his seventh straight during a 1,006-yard performance during the Buccaneers' Super Bowl championship season. Evans' accomplishment secured a ninth straight 1,000-yard campaign to start his NFL career, which is now the longest ever by three full seasons, extending his own record set in 2020. The 29-year-old Mike Evans entered the Panthers game coming off a hugely disappointing 29-yard receiving performance in Week 16 against the Arizona Cardinals, which pushed many fantasy football. Despite Tampa Bay's offense struggling for much of the year, the veteran wide receiver went off against the rival Panthers in Week 17, eclipsing 100 receiving yards in the first half to top 1,000 yards on the season. Fighting for an NFC South title on Sunday, Mike Evans also made NFL history for the Buccaneers. 11:34 AM EST In this story: Tampa Bay Buccaneers Mike Evans is the only player in NFL history to record eight consecutive 1,000-yard receiving seasons to start his career. Evans hosted the camp to more than 100 kids, for free, ages 8-14 through his Mike Evans Family Foundation. American gymnast Simone Biles' future at the Tokyo Olympics. Nine years after hanging up her leotard, Chellsie Memmel is back out on the competition floor! Chellsie impressed at Classics in her competitive debut on vault and beam and although she didn’t have the best showing on the latter, the potential is huge! With a jam-packed routine featuring a triple series and her signature standing arabian and illusion turn, Chellsie has the potential to reach a 6.1 start value on the event and be competitive with the rest of the field. After a low score on vault, Team USA pulled a key gymnast from the competition. TOKYO Simone Biles lost her way midair while vaulting in the women’s team final on Tuesday, then suddenly exited the competition, saying she wasn’t mentally prepared to compete. She came close to sticking the vault at several points leading up to the competition and if she can do it in competition-it is going to be a monstrous score. So, it’s helpful to watch her feat of athleticism in slow-motion, like in this video posted to TikTok by the NBC Olympics account: nbcolympics My heavens, Simone Biles. After a low score on vault, Team USA pulled a key gymnast from the competition. Despite taking a big hop backward during competition, Simone’s Yurchenko double pike was good for a 16.100-the highest score by any gymnast this Olympic cycle. / 7:04 AM / CBS News Although gymnast Simone Biles hasnt competed in more than 18 months, the four-time gold medalist showed in a video Friday that shes still just as talented. But instead of twisting, Biles’ new vault includes a second flip, done in a pike position. womens gymnastics team finals at the Tokyo Olympics, hopes were high for one of Team USAs biggest star athletes. In the past, Biles has done an Amanar vault: a Yurchenko with two-and-a-half twists. Let’s be real, you don’t want to miss the GOAT on any event, but her vault is what got everyone talking after the GK U.S. Updated: 11:24 AM EDT JWASHINGTON Going into the U.S. Waterfox will crash less often due to low-memory on the system, thanks to improvements integrated in to the Firefox code by Mozilla. For now, support is limited to YouTube on macOS 11 and newer with HGR compatible screens. Share options are now found under the file menu in the browser, and HDR video is also supported on Macs. On Mac devices, support for images containing ICC v4 profiles is now enabled. The browser's built-in PDF viewer supports form filling in the new version, and Picture-in-Picture mode supports video captions and subtitles now for select sites. Waterfox supports the AVIF format and hardware accelerated AV1 video decoding, the latter only on certain Windows systems with supported graphics processing units. Next to that, Waterfox's sandbox on Linux prevents access to the X Window System on Linux for web content.Īdditionally, "less restricted referrer policies" are now ignored to prevent privacy leaks, and the browser now supports the automatic updating "to HTTPS using HTTPS RR as Alt-Svc headers". Developers have improved web compatibilities as well. Waterfox G5.0 includes improved referrer tracking protection in Strict tracking protection mode and in private browsing mode. The release notes group most platform changes in the three groups security, media and operating systems. Waterfox G5.0 is based on Firefox ESR 102, which means that it supports the features of that release next to Waterfox-specific features. Most changes are made to the underlying platform. The official release notes list all major changes of the new release. Waterfox users may check the installed version by selecting Menu > Help > About Waterfox in the menu. Waterfox users who want to upgrade right away may download the latest version from the official project website to install it over the existing copy of the browser. If you want a higher browsing speed, you can always turn to Firefox's evil twin, Waterfox.The developer notes that the new version will roll out via automatic updates starting next week. Also, you can't run it in parallel with Firefox. Waterfox comes with almost no design elements of its own. The browser automatically imports everything you have on Firefox. It comes with the same features as Firefox, but it is significantly faster. Waterfox has a familiar design, so you can get used to it in no time. Also, you can find the same add-ons installed on Waterfox and you can also browse through the same extensions market and install them in just a few seconds, with a single click. Waterfox comes with all other features you are used to having in Firefox, so it doesn't take any time to adjust to this browser. For example, browsing through folders on Dropbox or other similar services feels almost like browsing through local folders in Windows Explorer. The time it takes to load a web page is significantly shorter. What's more, Waterfox will automatically import everything you have in Firefox, including bookmarks, quick dial items and even your installed plug-ins and it will also send any changes back to Firefox.Īlthough it looks very similar to Firefox, Waterfox feels faster when surfing the web. You can find the same home page and quick dial and even the same options menu. In terms of appearance, the browser is similar to Firefox in almost any way, from its tabs down to its last button. If you are familiar with Mozilla Firefox, you will feel right at home with Waterfox. Once it is installed, you can run the browser and visit your favorite websites right away, without installing any additional tools or services. It is available for Windows and Mac OS X and, as previously mentioned, it works only on 64-bit operating systems. The browser is offered completely free of charge and you can have it up and running in no time. It has a very familiar design, but it comes with its own appearance elements and features as well. Developed exclusively for 64-bit operating systems with Intel's C++ compiler, the browser offers a superior speed and performance, while keeping most of its original core code unchanged. Based on the popular Mozilla Firefox web browser, Waterfox aims to be one of the fastest browsers on the market. Take the CCleaner Free Edition as an example. Like CCleaner Professional Plus (1 year for 3PCs), you can also own Defraggier Professional (for speeding up hard disks), Recuva Professional (for recovering deleted files), and Speccy Professional (for monitoring hardware) after you get this product plan. You need to pay $69.95 for CCleaner Professional Plus (2 years for 3PCs) and then you can use it for 2 years on 3 different computers. CCleaner Professional Plus (2 Years for 3 PCs) You need to pay $39.95 for CCleaner Professional Plus (1 year for 3PCs) and then you can use it for 1 year on 3 different computers.īesides CCleaner, you can also own Defraggier Professional (for speeding up hard disks), Recuva Professional (for recovering deleted files), and Speccy Professional (for monitoring hardware). CCleaner Professional Plus (1 Year for 3 PCs) In this plan, CCleaner is the only product you can own. You need to pay $24.95 for CCleaner Professional and then you can use it for 1 year on 1 computer. Here, let’s talk about the prices of the three paid plans: CCleaner Professional (1 Year for 1 PC) The free edition has some standard privacy protection and cleaning features, and the professional edition has more advanced features. Besides, it can also be used to wipe the MFT free space of a drive or even the entire disk.ĬCleaner has 4 product plans: CCleaner Free, CCleaner Professional (1 year for 1 PC), CCleaner Professional Plus (1 year for 3 PC), and CCleaner Professional Plus (2 years for 3 PC). For example, this registry cleaner can find the missing references to shared DLLs, unused registration entries for file extensions, and missing references to application paths, and then fix the registry issues. Of course, it has other useful functions.ĬCleaner has a registry cleaner that can locate and correct the found issues in the Windows registry. It is useful when you want to free up disk space for new data.
On March 2, 1999, 14 of the videos were reprinted by Disney, and the final release in this format was Flik's Musical Adventure at Disney's Animal Kingdom on June 8, 1999. Some songs moved to newer volumes whilst newly remixed opening and closing songs appeared. Spanish language editions of some volumes were released as " Disney Canta Con Nosotros". This series incorporated Mickey's Fun Songs repackaged as Sing Along Songs (a three volume live-action set in the style of Disneyland Fun). The third series, beginning in December 1994 with Circle of Life, saw another new package design and the re-release of all previous volumes (excluding Fun with Music, repackaged as 101 Notes of Fun for the non-North American market). The second series began appearing in May 1990 with Under the Sea and in August of the same year with Disneyland Fun, featuring a new design and reissued volumes labeled One (1) through Twelve (12) in North America (worldwide, volume numbers differed with Australia continuing to number volumes while other countries discontinued the numbering). The first launched in October 1986 with Disney's Sing-Along Songs: Zip-A-Dee-Doo-Dah, followed by five more volumes. Issued beginning in 1986, there have been four distinct series. The footage of Von Drake and Jiminy Cricket were taken from several television programs (including the Walt Disney anthology television series) featuring the characters in the 1950s, 1960s, and 1980s. Professor Owl (here voiced by Corey Burton) hosts the viewers with his class as his assistants in some of the videos, while either Ludwig Von Drake (also voiced by Corey Burton) or Jiminy Cricket (voiced by Eddie Carroll) host others, and later volumes had no host at all. Early releases opened with a theme song introduction containing footage featuring Professor Owl and his class, seen originally in 1953 in two Disney shorts Melody and Toot, Whistle, Plunk and Boom as well as the TV anthology episode version of the latter for the wrap-arounds. Lyrics for the songs are displayed on-screen with the Mickey Mouse icon as a "bouncing ball". Disney's Sing-Along Songs was a series of videos, laserdiscs, and DVDs produced since 1986, featuring musical numbers from various Disney films, TV shows, and theme park attractions. |
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